B: If that's it. I find it very depressing.

A: Does this have anything to do with you?

B: Yes, it does.

A: How are you related to him?

B: He's my uncle.

A: Are these two related to each other?

B: No, there's no relation.

A: Are you involved in this?

B: No, I'm not.

A: How is this connected with that?

B:  There's no connection.

A: Is there any relationship between weight and health?

B: Yes, there is.

A: Does your work have anything common with his work?

B: No, nothing in common.